The study was conducted on 120 commercial pigs (DC1xTH12) and 120 commercial pigs (DC1xTH21) stage from 70 days to export, at Thuy Phuong Pig Research and Development Center to evaluate the effectiveness of probiotic supplements to increase immunity for DC1xTH12 and DC1xTH21 commercial pigs stage from 70 days to export. Pigs are divided equally into 4 lots by random method, ensuring uniformity in weight and age, each batch is repeated 3 times, each repetition is 30 animals. Lot DC: no preparations are added; Lot TN1: supplemented with 4 g/animal/day continuously during rearing; Lot TN2: supplemented with 5 g/animal/day continuously during rearing; Lot TN3: supplemented with 6 g/animal/day continuously during rearing. The results show that: The addition of probiotics to increase immunity has helped with DC1xTH12 and DC1 x TH21 commercial pigs stage from 70 days to exportreduce the incidence of diarrhea, reduce the incidence of respiratory disease, increase Average Daily Gain, reduce feed consumption and increase efficiency in raising with DC1xTH12 and DC1 x TH21 commercial pigs stage from 70 days to export. In which, probiotics were added to (DC1xTH12) and (DC1xTH21) commercial pigs stage from 70 days to export at the rate of 5 g/animals/day (lot TN2) for the best effect help reduce 10% of pigs suffering from diarrhea; reduce 3.4 - 6.7% of pigs suffering from respiratory diseases; increase from 5.0 to 5.4% of weight gain, reduce feed consumption by 2.0-2.4%.