Mekong delta of Vietnam is a fertile soil region, available fresh water and temperate climate, which is favorable for agricultural development and has a large contribution to food sources for domestic consumptions and exports. Animal husbandry is popularly considered as an important-agricultural production in the World, which makes many useful products such as meat, milk, eggs, organic fertilizer, pets, tourism, etc. It contributes to better income, improving human nutrition and intelligence and production diversifications based on certain production models for both the rich and poor producers. However the development of animal production in MD is still limited due to some objective and subjective reasons. In this paper the author will present the current production status, explain the reasons for applying advanced technologies and development principles of sustainable production in global trends of adaptation to climate change, new technologies, financial conditions, human resources and technically applying levels. While there are advantages in production for industrial farms, the traditional ones with their limited resources must need more support on development policies and material investments from the government to make more quality and safe animal products for local consumption and export with better benefits on economic development, environment and society.