The aim of this study to assess the estrus rate, pregnancy rate and breeding coefficient of HF crossbred cows when artificially inseminated with Wagyu bull sperm raised in the area of Ba Vi Cow and Grassland Research Center. The experiment was conducted on 245 healthy HF crossbred cows, free of infectious and reproductive diseases, with normal fertility, no defects in appearance as well as in the reproductive organs; rear or breeding cows, aged from 3-6 years, weight ≥ 300 kg for post-productive cows and ≥ 400 kg for breeding cows. During the experiment, the estrus rate, pregnancy rate and mating coefficient were monitored. The results were obtained, the estrus response rate of the Holstein Friesian cattle group (89.79%), the rate of pregnant cows through 2 mating times reached 74.55% and had a mating coefficient of pregnancy of Holstein Friesian cattle of 2.12 doses/pregnancy through 2 mating.