This study was conducted at Ninh Binh Plant Breeding Research and Development Centre – Hung Tuyen Company on the Summer – Autumn period in 2021 to identify the dietary on Three-way crossbred pig from Duroc, Landrace and Yorkshire genetics in two periods: 25-50kg and 50 – 100kg. Completely random experiment design was conducted on 90 pigs, starting from 20kg, divided into three treatments, each treatment had 30 pigs with the sex ratio between gilt/barrow pig is 1:1and 3 times repeated (10 pigs/each repeated). All of experiments included: treatment 1 had LysTH/ME equivalent to 95%, treatment 2 had LysTH/ME equivalent to 100%, and treatment 3 had LysTH/ME equivalent to 105% compare with Ninh Thi Len et al., 2011 recommendation. The results revealed: LysTH/ME effected on Average Daily Gain (ADG), Feed Conversion Ratio (FCR) and Meat composition traits. The suitable of LysTH/ME ratio in pig dietary is 2.90 g/Mcal at 20-50kg and 2.5 g/Mcal at 50 – slaughter period.