The objective of this study was to evaluate goat manure on growth, yield and quality of Setaria grass (Setaria sphacelata). The experiment was arranged in a completely randomized design with five treatments and five replications. The treatments were PD0, PD23, PD47, PD71, and PD95 corresponding to the goat manure of 0, 23, 47, 71, and 95 ton/ha/year, respectively. Goat manure applications were before planting and after planting 14 and 28 days for the first planting time, while the others were two days after harvesting. The growth parameters, yields of fresh and dry matter, crude protein and neutral detergent fiber of the grass were determined for three cuttings, which included the first cutting (60 days after planting) and the second and third cuttings (35 days after the previous cuttings). The results showed that the increase of goat manure as a fertilizer application for grass enabled to increase the growth and yield of Setaria grass. Setaria grass in the trial gave the highest efficiency with the using PD71. It was concluded that planting Setaria grass with the goat manure application of 71 ton/ha/year should be recommended for the production practices.