The study was carried out at the Pig Farm of the center of High-Tech application in Agriculture Ben Tre, Phuoc Thanh hamlet, Tam Phuoc commune, Chau Thanh district, Ben Tre province, from June 2020 to June 2021. The aim was to propose solutions to increase resistance in the prevention of diseases in breeding pigs. The pigs were assigned into 3 treatments in a completely randomized design: control treatment (DC), adding premix vitamin treatment (VIT), adding β-glucan treatment (BETA) and 15 replications. The results indicated that sows in VIT treatment were earlier on estrus, and the first insemination was the highest (73.3%), the next BETA (66.7%) and DC (60%). The average gestation time of experimental sows was 113.8-114.8 days; the number born alive was 9.67-10.87 piglets/litter and the number of weaned pigs was 9.40-10.53 piglets/litter (P>0.05). Individual birth weight was 1.40-1.43 kg/piglet and weaning weight was 6.96-7.43 kg/piglet of 03 treatments that were similar. The analyzed results of sera samples to detection of antibodies against Foot-and-mouth disease virus type O by competitive ELISA technique showed that: after injecting the Foot-and-mouth vaccine, the concentration of antibodies against Foot-and-mouth disease virus was high at the point time of sows birth their piglets via the OD index in the treatments. Piglets at 7 old days in 3 treatments were responded with antibody again Foot-and-mouth disease virus and significantly decreased in piglets at 21 old days.