The objective of this study was to evaluate adaptability, growth and reproductive performance of Senepol beef cattle under Vietnam condition. 30 imported Senepol cows at 14 to 18 months old and 14 Senepol calves borned in Vietnam at 6 months old were used in this trial. The experiment was carried out in Bavi Cattle and Forage Research Center from November 2018 to March 2020. The results were shown that: (1) Adaptability of imported cows: the walking and eating time were taken from 11 to 17 h per day; the rest and ruminating time were taken from 7 to 13 h per day; sleeping time was from 3 to 5 h per day. In Winter - Spring season the body temperature in the morning and in the afternoon ranging from 37.40 to 38.30°C, breathing rate from 29.2 to 48.7 times per minute and heart rate from 62 to 70 times per minute. In the Summer - Autumn the body temperature were 38.30°C in the morning and 39.20°C in the afternoon, the breathing rate from 31.8 to 51.5 times per minute and heart rate from 64 to 73 times per minute; (2) Growth performance: The body weight of imported cows at 14 month old was 384.87 kg, 18 month (417.46 kg), 22 month (508.26 kg) and 26 month (582.63 kg). The growth rate at 14 months to 26 months old in imported cows ranged from 0.592 to 0.756 kg/head/day. The average birth weight of calves borned in Vietnam was 33.9 kg compared with 33.9 kg of imported cows, the body weight at 2 months old were 113.5 kg (imported cows) and 114.1 kg (borned in Bavi), the body weights at 6 month were 174.1 kg (imported cows) and 176 kg (borned in Bavi); (3) Reproductive performance: The age at first oestrus was 20.67 months, age at first insemination was 21.74 months, body weight at the first insemination was 405.5 kg, conception rate at the first insemination was 73.91% and number of AI per conception reached 1.46.