Application artificial insemination to develop the F1 Murrah buffalo herd in Vinh Phuc province from 2016-2018. The study on investigation to select the growth and reproductive ability of buffalo herd in Tam Dao and Lap Thach district of Vinh Phuc province showed that the body weight of female buffalo at 6 year of age is 382.63 and 391.38 kg; first mating age 34.72 and 35.63 months; the distance between two litters 17.68 and 16.89 months. Using 310 Murrah buffalo straw semen inseminated for 240 female buffaloe in two districts. There are 153 pregnant buffaloes. The pregnancy rate was 49.35%. 2.03 straw semmen were used for a pregnant buffalo. The distance between two litters is lower compared to investigated buffaloes in the area. F1 hybrid buffaloe born with the AI method has a good growth in farmer conditions. The birth weight of male F1 hybrid buffaloe is 29.71 kg and 28.58 kg with female. At 12 months old the male F1 hybrid buffaloe reached 186.58 kg and the female reached 184.75 kg. At 18 months old the male F1 hybrid buffaloe reached 240.19 kg and the female reached 239.93 kg. The growth ability of bybrid buffalo to 18 months of age is higher than local buffalo from 12.5% - 20.7%.