This study was conducted to evaluate the effects of dietary enzyme supplementation on the growth performance and feed utilization efficiency of French Muscovy ducks (4-10 weeks old) raised on slatted floors. A total of 144 French Muscovy ducks at four weeks old were allotted in a completely randomized design of four treatments, three replicates, consisting of diets supplemented with 0% (control), 0.1%, 0.2%, and 0.3% enzyme. The results indicated that the Muscovy ducks fed the diet with 0.3% enzyme supplementation achieved the highest 10-week body weight (2358.90 g/bird) and overall average daily gain (38.16 g/bird/day). The FCR was lowest in the 0.3% enzyme treatment (2.77). Furthermore, the amount of residual nutrients content in their feces from the 0.3% enzyme treatment group was the lowest (p < 0.05). In conclusion, supplementing the feed of Muscovy ducks with 0.3% enzyme significantly improves weight gain and nutrient digestibility.