The experiment was conducted on 1,350 “Sen” muscovy ducks for breeding and was conducted at Dai Xuyen Duck Breeding and Research Center. Starting from 1 day of age, experimental muscovy ducks were wearing the number of wings each, were kept completely in a cage (with barn filler) with a naturally ventilated playground. Experiments to determine the appropriate protein level in the muscovy duckling, prepare laying and laying stages with different protein levels at the duckling stages (0-4) weeks of age including: 19; 20 and 21%, ME 2900 kcal/kg; 5-8 weeks of age including: 17; 18 and 19%, ME 2900 kcal/kg; prepare laying stage (9 - 26 weeks of age) includes: 13; 14 and 15%; ME 2900 kcal/kg; laying stage (27 - 78 weeks of age): 15; 16 and 17% ME 2650 Kcal/kg, arranged in 3 experimental groups: Treatment 1 (at 19% - 17% - 13% - 15%); treatment 2 (20% - 18% - 14% - 16%); treatment 3 (21% - 19% - 15% - 17%) corresponding to the protein level arranged in the stages of duckling (0 - 4 weeks of age and 5 - 8 weeks of age) - prepare laying - laying. The results show that: Sen muscovy duck breeding in experimental group 2 had the highest results: the rate of feeding the duckling and gilts stage was 92.22%, the body weight of Sen muscovy duck at 26 weeks of age was 3124.01 gram/male and 2031.53 gram/female, egg production 89.18 eggs /female/ 52 weeks of lay, feed consumption of 6.88 kg/10 eggs, the rate of eggs with embryos was 95.67%; hatching rate/number of eggs with embryos 86.87%; The hatching rate/total eggs hatched was 82.00% and the hatching rate 1/number of ducklings hatched was 92.68%. Economic efficiency was 69,842,574 VND, interest /female 310,411 VND, mixed income index (MI), profit (Pr), mixed income / total cost and mixed income / labor. reaching the highest level in the experimental lot 2 with the corresponding indices of 107,342,574 VND; 83,382,574 VND; 0.50 and 4.47. Use of feed with protein level at 20% and 18% duckling, 14% prepare laying and 16% laying stages Sen muscovy duck breeding is most effective.