The objection of this study was evaluation of feeding method to prevetion of metabolism disorder in dairy cow. The trial were divivingon 2 periods as dry period (60 days before calving) and during early lactation (100 days). The location of trial in BaVi Cattle and Forage Research Center and Animal Biotechnology Centre (ABC) from January to June, 2019. The both regions, forty dairy cattle were randomized in two groups in each group in 20 cows (group 1 is control and group 2 is experimental) with similarly on body weight, BCS, milk yield, lactation. Two groups were similarly with ration and nutitional value, the experimenal group (group 2) on 60 days before delivery was supplementation with Magnesium sulphate (MgSO4.7H2O) (34%), Ammonium Chloride (NH4Cl) (59%), Ammonium sulphate (NH4)2SO4) (1.5%), Calcium carbonate (CaCO3) (5.5%); on early lactation was supplementation with 13% Sodium bicarbonate (NaHCO3); 13% sodium sesquicarbonate (Na3H(CO3)2; 6% magesium oxide (MgO); 26% sodium bentonite (Al2H2Na2O13Si4); 12% calcium carbonate (CaCO3) và 30% potassium carbonate (K2CO3). The results were showed that supplementation of buffer mixtures at different stage in the experiment was effected on feed intake, milk protein and milk fat were also effect in the experiment. The group 2 was maintaining the rumen pH, urine ketone above incidence ketosis and milk fever better when compared with group 1.