The arm of this study was to evaluate the effect of applying veterinary hygiene methods for disease prevention on growth and reproductive performance of Hoa Lan ducks. The experiment was conducted at a duck household in Tien Giang province from 2017 to 2019. One day-old ducklings were aranged into 2 groups, in each group there were 40 males and 160 females, 3 repetitions. The Group I: Applying veterinary hygiene methods for disease prevention, Group II (control): Current methods of duck rearing the farmers applying. The results show that applying veterinary hygiene methods for disease prevention reduced rate of respiratory and diarrhea disease (3.8 and 2.5 times respectively), increased survival rate (2.1-2.4%), laying age was sooner 4 days (144.3 vs 148.3 days) comparing to in the control group. The egg production was 218.32 egg/female/52 weeks (7.69 eges more than in the control), laying rate of 59.79% (2.27% higher than in the control). FCR/10eggs was lower (3.31 kg vs 3.47 kg). Hatching rate was not effected. Applying veterinary hygiene methods for disease prevention in Hoa Lan ducks rearing increased economic efficiency to farmer (9.2%) comparing to current methods of duck rearing the farmers applying.