A study was conducted at the Experimental farm in Long Hoa commune, Binh Thuy district, Can Tho city to evaluate the effects of different supplementation levels of brewery waste (BW) in Brassica cauliflora Lizg residue basal diets on nutrient utilization, weight gain, apparent nutrient digestibility and economic returns of growing crossbred rabbits. The feeding trial was a completely randomized design with 5 treatments and three replications. The treatments were 5 supplement levels of 0, 100, 150, 200 and 250 g BW/rabbit/day (correspondings to the BB0, BB100, BB150, BB200 and BB250 treatments). There were 4 growing crossbred rabbits at 7 weeks of age (sexual balance) per experimental unit and the experimental time lasted in 10 weeks. The nutrient digestibility trial was done on 12 week- old crossbred rabbits in 7 days to evaluate apparent nutrient digestibility and nitrogen retention. The results showed that Brassica cauliflora Lizg residue intakes gradually decreased with increasing supplement levels of brewery in the diets, while brewery intakes increased (P<0.05). The daily intakes of DM, OM, CP and NDF were the significantly highest for the BB250 treatment (P<0.05). The rabbits supplemented 250 g BW in the BB250 treatment had higher daily weight gain and final live weight than those given others (P<0.05). The CP and NDF digestibility coefficients were improved in the diets supplemented BW (P<0.05). It was concluded that a level of 250 g brewery waste supplement in Brassica cauliflora Lizg residue basal diet had higher growth rate, nutrient digestibility, N retention and gave better profits.